The Chemistry and in Vitro Cytotoxicity Study of Manganese Oxide Nanostructures PDF Download. Download free ebook of The Chemistry and in Vitro Cytotoxicity Study of Manganese Oxide Nanostructures in PDF format or read online by Yiu-Ming Chan,陳耀明 9781361427910 Published on 2017-01-27 by Open Dissertation Press
This dissertation, |The Chemistry and in Vitro Cytotoxicity Study of Manganese Oxide Nanostructures| by Yiu-ming, Chan, 陳耀明, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled THE CHEMISTRY AND IN VITRO CYTOTOXICITY STUDY OF MANGANESE OXIDE NANOSTRUCTURES Submitted by Chan Yiu Ming for the degree of Doctor of Philosophy at The University of Hong Kong in September 2007 Size-controlled Mn O nanoparticles were synthesized by hydrothermal synthesis 3 4 using ligand-coated Mn O as the metal precursor. The nanostructures were 2 3 characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), and powder X-ray diffraction (XRD). The size and distribution of the nanostructures were strongly affected by the oxidation state of the metal precursor, ethanol concentration, and the functional group presence on the ligands. Smaller Mn O 3 4 nanoparticles were produced by decreasing the oxidation state of the metal precursor, increasing the volume ratio of the ethanol, and introducing ligands containing amino groups for the reduction of the nanomaterials or hydroxyl groups for the enhancement of the hydrophilic properties during hydrothermal synthesis. The morphology of Mn O 3 4 was changed from nanoparticle to nanorod with ligands containing a carboxylate group residual. The hausmannite nanoparticles had a mean diameter of 7.8 1.4 nm when Mn O coated with mucic acid was treated by hydrothermal synthesis with 100% 2 3ethanol at 160C for eight hours. Unbranched MnOOH nanowires were also synthesized by hydrothermal synthesis. The length of the nanowires depended on the precursor, the ethanol concentration, and the ligands used during the synthesis. Elongation of the nanowires occurred with the introduction of ligands. Increasing the number of amino groups on the ligands had a suppression effect on the formation of MnOOH nanowires. Increasing the carboxylate groups and the hydroxyl groups on the ligands had a weaker elongation effect compared with the hydrophobic ligands. MnOOH nanowires with a mean diameter of 30.1 10.5 nm and a length up to 5.0 0.8 m could be obtained by the synthesis of Mn O coated 2 3 with hexanoic acid in the hydrothermal synthesis with 40% ethanol at 160C for eight hours. The cytotoxicity of Mn O nanoparticles and MnOOH nanowires were investigated 3 4 by in vitro MTT assay. BJ, Hep-G2, and HEK-293A cells were used as models for the evaluation. The Mn O nanoparticles showed a greater cytotoxicity than the MnOOH 3 4 nanowires. This effect could be increased by a decrease in the size of the nanoparticles. Hep-G2 cells had the highest tolerance towards Mn O nanoparticles, whereas 3 4 HEK-293A was the most sensitive. The cell proliferation rate of Hep-G2 was stimulated by nanoparticles with a mean size larger than 70 nm. The MnOOH nanowires did not have a cytotoxic effect on the entire cell sample; instead, it had a stimulation effect on the cell proliferation of Hep-G2 and HEK-293A cells of more than 300%. This unique biological expression was caused by the different size of the nanostructures, rather than by the presence of the ligands on the surface. The in vitro studies suggest that the cytotoxicity of hausmannite nanoparticles decreases after the regeneration from cells. The cell signalling pathway was determined by immunoblot analysis. A reduction in the amount of procaspase-3 and the generation of caspase-3 were observed with cell death caused by apoptosis. The increase in cell proliferation produced by feitknechtite nanowires
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