Utilizing DNA Nanostructures for the Study of the Force Dependency of Receptor - Ligand Interactions PDF Download. Download free ebook of Utilizing DNA Nanostructures for the Study of the Force Dependency of Receptor - Ligand Interactions in PDF format or read online by Randy Alexander Patton Published on 2017 by
All biological motion is ultimately driven by molecular scale interactions and forces. Only in recent years have technologies and techniques been developed capable of probing interactions at forces of nanoNewtons to picoNewtons, and at length scales of Microns to Angstroms. However, these techniques (such as Optical Traps, Magnetic Tweezers, and Atomic Force Microscopy) are limited in their potential applications by their physical size and low experimental throughput. This dissertation presents the development of a DNA Origami based nanosensor, specifically designed to perform high-throughput, single-molecule force spectroscopy measurements. DNA Origami is a nanofabrication process driven by the specificity of Watson-Crick nucleobase pairing. By engineering the sequence of a series of oligonucleotides, Megadalton scale assemblies can be assembled through a molecular self-assembly process at the nanoscale. Here, we exploit this technique to utilize the entropic elasticity of the DNA molecule, generating a force on a bimolecular interaction the nanostructure facilitates. This interaction is monitored via an optical technique, Forster Resonance Energy Transfer, enabling high throughput and multiplexed measurements of biomolecular binding kinetics.
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